Ethanol → HCID 178436474、化合物

HRID 2103946ノート

反応式

HRID 2103946 の反応式
[SH:1][C:2]1[N:3]=[N:4][NH:5][CH:6]=1.[Cl-].[CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[CH2:9].[CH2:16](O)C>>[CH:8]([C:10]1[CH:15]=[CH:14][C:13]([CH2:16][S:1][C:2]2[NH:3][N:4]=[N:5][CH:6]=2)=[CH:12][CH:11]=1)=[CH2:9]

参加物

4

反応物 3

HCID 702EthanolHCID 180086044-Vinylbenzene chlorideHCID 178527738HCID 178527738、化合物

生成物 1

HCID 178436474HCID 178436474、化合物

実験手順

10 mmole of 4-mercapto-1H-1,2,3-triazole (sodium salt) was dissolved in 20 ml of ethanol in stirring. 10 mmole of 4-vinylbenzene chloride was added, and stirred overnight. The precipitate was removed by filtration, the solvent in the filtrate was removed in vacuum. The obtained solid was separated with a Si gel column (solvents: 1 ethylacetate/1 hexane in volume). 2.1 g product was obtained. 1H NMR (CD3Cl): 7.46 (1H, s), 7.31 (2H, d, JH-H=8.16), 7.18 (2H, d, JH-H=8.16), 6.67 (1H, m), 5.71 (1H, d, JH-H=16.68), 5.22 (1H, d, JH-H=11.68), 4.09 (2H, S).

後処理

  1. stirringstirred overnight
  2. customThe precipitate was removed by filtration
  3. customthe solvent in the filtrate was removed in vacuum
  4. customThe obtained solid was separated with a Si gel column (solvents: 1 ethylacetate/1 hexane in volume)

出典と根拠

ORDレコード
ord-12b93ff23d8946679ad9388ac73ba4cd
出典データセット
uspto-grants-2009_08
特許番号
US07576165B2

反応ノート

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