Isopropanol → HCID 11567771、化合物

HRID 2104162ノート

反応式

HRID 2104162 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=O.[F:18][C:19]([F:27])([F:26])[C:20](=[O:25])[CH2:21][C:22](=O)[CH3:23].C(O)(C)C>CCCCCCC.C(OCC)(=O)C>[Br:8][C:5]1[CH:4]=[C:3]2[C:2](=[CH:7][CH:6]=1)[N:1]=[C:22]([CH3:23])[C:21]([C:20](=[O:25])[C:19]([F:27])([F:26])[F:18])=[C:9]2[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 3776IsopropanolHCID 739431,1,1-Trifluoro-2,4-pentanedioneHCID 1359860(2-Amino-5-bromophenyl)(4-fluorophenyl)methanone

生成物 1

HCID 11567771HCID 11567771、化合物収率 80%

試薬・触媒・溶媒 1

HCID 21899848Ethylacetate heptane溶媒

実験手順

The title compound was prepared from (2-Amino-5-bromo-phenyl)-(4-fluoro-phenyl)-methanone [example A2] and 1,1,1-trifluoro-2,4-pentanedione according to the procedure of example 1, except that the solvent was isopropanol, the reaction time was of 16 h and heptane/ethyl acetate (1:2) was used. Yield: 80%; MS: m/z=411/413 (M).

出典と根拠

ORDレコード
ord-bd66588853bb48649329f174650ca4bd
出典データセット
uspto-grants-2009_08
特許番号
US07576217B2

反応ノート

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