3-(Trifluoromethyl)phenylboronic acid → Pyridin-2-yl{8-(Trifluoromethyl)-4-[3-(Trifluoromethyl)Phenyl]Quinolin-3-yl}Methanone

HRID 2104479

反応式

HRID 2104479 の反応式
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=[O:17].[F:24][C:25]([F:36])([F:35])[C:26]1[CH:27]=[C:28](B(O)O)[CH:29]=[CH:30][CH:31]=1>>[N:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[C:16]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[C:30]1[CH:29]=[CH:28][CH:27]=[C:26]([C:25]([F:36])([F:35])[F:24])[CH:31]=1)=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]([F:15])([F:14])[F:13])=[O:17]

参加物

3

反応物 2

HCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 66913162(4-Chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone

生成物 1

HCID 11408200Pyridin-2-yl{8-(Trifluoromethyl)-4-[3-(Trifluoromethyl)Phenyl]Quinolin-3-yl}Methanone

実験手順

This compound was prepared using the procedure of Example 1, step 5 using (4-chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone in place of [4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone and 3-trifluoromethylphenylboronic acid in place of phenyl boronic acid. MS (ESI) m/z 447 ([M+H]+); Anal. Calcd for C23H12F6N2O: C, 61.89; H, 2.71; N, 6.28. Found: C, 61.70; H, 2.66; N, 6.14.

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-22f17cbfab044b1bab0d2763b6e86ad5
出典データセット
uspto-grants-2009_08
特許番号
US07576215B2

関連ノート

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