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Acetyl chloride → Phenyl[4-Phenyl-8-(Trifluoromethyl)Quinolin-3-yl]Methyl Acetate

HRID 2104494
ノート
印刷プレビュー

反応式

HRID 2104494 の反応式
[C:1]1([CH:7]([C:9]2[CH:10]=[N:11][C:12]3[C:17]([C:18]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:16][CH:15]=[CH:14][C:13]=3[C:25]([F:28])([F:27])[F:26])[OH:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:36](Cl)(=[O:38])[CH3:37]>C(Cl)Cl>[C:36]([O:8][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:18]=1[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[CH:16][CH:15]=[CH:14][C:13]=2[C:25]([F:28])([F:26])[F:27])(=[O:38])[CH3:37]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 11222693Phenyl[4-Phenyl-8-(Trifluoromethyl)Quinolin-3-yl]Methanol

生成物 1

HCID 66914489Phenyl[4-Phenyl-8-(Trifluoromethyl)Quinolin-3-yl]Methyl Acetate収率 79.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanol (Example 34, 0.050 g, 0.132 mmol) was taken into CH2Cl2 (3 mL). Next, triethylamine (0.1 mL, 0.70 mmol) was added followed by acetyl chloride (0.05 mL, 0.70 mmol). The reaction was allowed to stir for 2 hours. The solvent was removed and the resulting material was taken up into an Ether/water/5% HCl solution. The layers were separated and the organic layer was washed once more with 5% HCl, dried over magnesium sulfate and concentrated. The product was purified via column chromatography using 7% ethyl acetate in hexane as the eluent to afford the product as a white solid (0.044 g, 79.4%). MS (ESI) m/z 422 ([M+H]+); Anal. Calcd. for C25H18F3NO2: C, 71.25; H, 4.31; N, 3.32. Found: C, 71.15; H, 4.11; N, 3.21.

後処理

  1. customThe solvent was removed
  2. customThe layers were separated
  3. washthe organic layer was washed once more with 5% HCl
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated
  6. customThe product was purified via column chromatography

出典と根拠

ORDレコード
ord-f88f7d3578f24dc594df7b4f93372a09
出典データセット
uspto-grants-2009_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07576215B2

反応ノート

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