3-Aminophenylboronic acid → Ethyl 4-(3-aminophenyl)-8-(trifluoromethyl)quinoline-3-carboxylate

反応式

[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1Cl)=[CH:13][CH:12]=[CH:11][C:10]=2[C:17]([F:20])([F:19])[F:18])=[O:5])[CH3:2].[NH2:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][CH:27]=1>>[NH2:21][C:22]1[CH:27]=[C:26]([C:15]2[C:14]3[C:9](=[C:10]([C:17]([F:20])([F:19])[F:18])[CH:11]=[CH:12][CH:13]=3)[N:8]=[CH:7][C:6]=2[C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:25]=[CH:24][CH:23]=1

参加物

反応物 2

HCID 922693-Aminophenylboronic acid

HCID 725465Ethyl 4-chloro-8-(trifluoromethyl)quinoline-3-carboxylate

生成物 1

HCID 66913532Ethyl 4-(3-aminophenyl)-8-(trifluoromethyl)quinoline-3-carboxylate

実験手順

The title compound was prepared from 4-chloro-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester and 3-aminophenylboronic acid according to the procedure of Example 1. MS (ES) m/z 361.0;

出典と根拠

ORDレコード: ord-fe686f824dfd4e698318e3ceccfdd095
出典データセット: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07576215B2

反応ノート

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