HCID 178418866、化合物 → HCID 178420160、化合物
反応式
[C:1]1([C:7]2[N:11]=[C:10](S)[NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CCO.[Ni]>[C:1]1([C:7]2[N:11]=[CH:10][NH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
3-phenyl-1,2,4-triazole-5-thiol (1.80 g, 10.2 mmol) and Raney Ni (rinsed with EtOH 3×, 3 g) in 30 mL EtOH was refluxed for 1.5 h. The mixture was filtered and concentrated. The crude yellow oil was redissolved in EtOAc and filtered through 1″ SiO2, then concentrated to afford 1.32 g of Intermediate 17.1 as a white crystalline solid.
後処理
- filtrationThe mixture was filtered
- concentrationconcentrated
- dissolutionThe crude yellow oil was redissolved in EtOAc
- filtrationfiltered through 1″ SiO2
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-2add41df076943448c8cab3cff40d265
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07576098B2
反応ノート
読み込み中…