Hydroxylamine → 4-((4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)-N'-hydroxybenzamidine

HRID 2104971ノート

反応式

HRID 2104971 の反応式
[Br:1][C:2]1[N:3]=[C:4]([N:26]([CH2:35][C:36]2[CH:41]=[C:40]([O:42][CH2:43][CH3:44])[CH:39]=[C:38]([O:45][CH:46]([CH3:48])[CH3:47])[C:37]=2[F:49])[C:27]2[CH:34]=[CH:33][C:30]([C:31]#[N:32])=[CH:29][CH:28]=2)[N:5]([C:7]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=1.[OH2:50].[NH2:51]O>CS(C)=O>[Br:1][C:2]1[N:3]=[C:4]([N:26]([CH2:35][C:36]2[CH:41]=[C:40]([O:42][CH2:43][CH3:44])[CH:39]=[C:38]([O:45][CH:46]([CH3:48])[CH3:47])[C:37]=2[F:49])[C:27]2[CH:28]=[CH:29][C:30]([C:31]([NH2:51])=[N:32][OH:50])=[CH:33][CH:34]=2)[N:5]([C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:6]=1

参加物

5

反応物 3

HCID 787HydroxylamineHCID 962WaterHCID 688128174-((4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile

生成物 1

HCID 866079354-((4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)-N'-hydroxybenzamidine

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

To a solution of Intermediate 28.1 (2.00 g, 2.8 mmol) in 3M NH2OH in DMSO (6 mL) (prepared according to example 1) was heated at 60° C. for 3 h. The reaction mixture was poured into water and the resultant precipitate was collected by filtration and dried in vacuo to afford Intermediate 66.1, which was used in the following step without purification.

後処理

  1. filtrationthe resultant precipitate was collected by filtration
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-04f85076da30401888a17ac344529ea9
出典データセット
uspto-grants-2009_08
特許番号
US07576098B2

反応ノート

読み込み中…