化工社化工社 化学情報印刷レポート · 研究参考用
Triethylsilane → 2-Chloro-4-ethyl-1-fluorobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylsilane | HCID 12052 | — |
| 反応物 | 3'-Chloro-4'-fluoroacetophenone | HCID 520422 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | 2-Chloro-4-ethyl-1-fluorobenzene | HCID 18711878 | 28.3% |
反応手順
To a solution of 3′-chloro-4′-fluoroacetophenone (5.2 g, 30.1 mmol) in 30 mL TFA, was added triethylsilane (14.4 mL, 90.4 mmol). The mixture was stirred at rt for 15 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 1.35 g of Intermediate 221.1 as a colorless oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07576098B2 |
| 出典データセット | uspto-grants-2009_08 |
| ORD ID | ord-e628bb131f7d41c080af62910a34c143 |
| 出典メモ | uspto-grants-2009_08 |