1,2-Dichlorobenzene → 1-(5-carboxypentyl)-5-methoxy-2,3,3-trimethyl-3H-indolium bromide

HRID 2105102

反応式

HRID 2105102 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]2([CH3:14])[CH3:13].[Br:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22].ClC1C=CC=CC=1Cl>C(OCC)C>[Br-:15].[C:21]([CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][N+:8]1[C:9]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2)[C:6]([CH3:14])([CH3:13])[C:7]=1[CH3:12])([OH:23])=[O:22]

参加物

5

反応物 3

HCID 72391,2-DichlorobenzeneHCID 202106-Bromohexanoic acidHCID 110953925-Methoxy-2,3,3-trimethyl-3H-indole

生成物 1

HCID 688166851-(5-carboxypentyl)-5-methoxy-2,3,3-trimethyl-3H-indolium bromide収率 80.9%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
100 °C

実験手順

To 5-methoxy-2,3,3-trimethyl-3H-indole (1.9 g) was added 6-bromohexanoic acid (3 g) and 1,2-dichlorobenzene (10 ml). The mixture was heated to 100° C. for 3 hours and then allowed to cool to room temperature. Diethyl ether was added and the precipitated material removed by filtration. Drying in a vacuum oven gave the product (3.12 g).

後処理

  1. temperatureto cool to room temperature
  2. customthe precipitated material removed by filtration
  3. customDrying in a vacuum oven

出典と根拠

ORDレコード
ord-3854d7164f204f69a8ecac9545dc67fe
出典データセット
uspto-grants-2009_08
特許番号
US07579140B2

関連ノート

読み込み中…