Hydrochloric Acid → 2-[[(3-Chloro-2-fluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

HRID 2105147ノート

反応式

HRID 2105147 の反応式
Br[C:2]1[C:11]2[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=2[N:5]=[C:4]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:16]=2[F:22])[N:3]=1.Cl.[OH2:24]>>[Cl:21][C:17]1[C:16]([F:22])=[C:15]([CH2:14][S:13][C:4]2[N:3]=[C:2]([NH:10][C@H:11]([CH3:2])[CH2:6][OH:24])[C:11]3[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=3[N:5]=2)[CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 225059834-Bromo-2-[[(3-chloro-2-fluorophenyl)methyl]thio]-7(8H)-pteridinone

生成物 1

HCID 688162692-[[(3-Chloro-2-fluorophenyl)methyl]thio]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

実験手順

The titled compound was prepared by the method of Example 2, step (f) using the product from example 6, step (e) (75 mg). The reaction mixture was poured into water and acidified with conc. HCl. The suspended solid was removed by filtration, dried in air and recrystallized from acetonitrile to give a yellow solid (37 mg).

後処理

  1. customThe suspended solid was removed by filtration
  2. customdried in air
  3. customrecrystallized from acetonitrile

出典と根拠

ORDレコード
ord-170620d656e642c7acf823f851d87647
出典データセット
uspto-grants-2009_08
特許番号
US07579342B2

反応ノート

読み込み中…