2-[[(2,3-Difluorophenyl)methyl]thio]-4,5,6-pyrimidinetriamine → 4-Amino-2-[[(2,3-difluorophenyl)methyl]thio]-6-(trifluoromethyl)-7(8H)-pteridinone
反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:11]1[N:16]=[C:15]([NH2:17])[C:14]([NH2:18])=[C:13]([NH2:19])[N:12]=1.[F:20][C:21]([F:28])([F:27])[C:22](=O)[C:23]([O-])=[O:24]>>[NH2:17][C:15]1[C:14]2[N:18]=[C:22]([C:21]([F:28])([F:27])[F:20])[C:23](=[O:24])[NH:19][C:13]=2[N:12]=[C:11]([S:10][CH2:9][C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])[N:16]=1参加物
3
実験手順
The sub-titled compound was prepared from the product of Example 2, step (c) (5 g) and trifluoropyruvate (10 ml) using the method of Example 2, step (d).
出典と根拠
- ORDレコード
- ord-94de552c9bc74a318c8cd84c5ac8d62f
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07579342B2
反応ノート
読み込み中…