化工社化工社 化学情報印刷レポート · 研究参考用
Phenylethanolamine → 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-[(2-hydroxy-2-phenylethyl)aminomethyl]indol-2-yl]isoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylethanolamine | HCID 1000 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone | HCID 86628227 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-[(2-hydroxy-2-phenylethyl)aminomethyl]indol-2-yl]isoindolinone | HCID 68487304 | — |
反応手順
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 2-amino-1-phenylethanol (27 mg, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-5-[(2-hydroxy-2-phenylethyl)aminomethyl]indol-2-yl]isoindolinone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6dddbc217146496e8af5e30483ced0a9 |
| 出典メモ | uspto-grants-2010_06 |