5-Ethyl-2,4(1H,3H)-pyrimidinedione → 2-chloro-5-ethyl-3H-pyrimidin-4-one

HRID 2105314ノート

反応式

HRID 2105314 の反応式
[CH2:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=O)[NH:7][CH:8]=1)[CH3:2].[Cl:11]C1NC(=O)C(C)=C(C)N=1>>[Cl:11][C:6]1[NH:5][C:4](=[O:10])[C:3]([CH2:1][CH3:2])=[CH:8][N:7]=1

参加物

3

反応物 2

HCID 732675-Ethyl-2,4(1H,3H)-pyrimidinedioneHCID 1356676192-chloro-5,6-dimethyl-3H-pyrimidin-4-one

生成物 1

HCID 112059252-chloro-5-ethyl-3H-pyrimidin-4-one収率 67%

実験手順

The title compound was prepared in 67% yield from 5-Ethyl-1H-pyrimidine-2,4-dione utilizing a method analogous to the preparation of 2-chloro-5,6-dimethyl-3H-pyrimidin-4-one (see Lee, et al., WO 9605177). 1H NMR (400 MHz, DMSO-d6): δ 13.21 (br s, 1H), 7.90 (br s, 1H), 2.39 (q, 2H, J=7.6 Hz), 1.08 (t, 3H, J=7.6 Hz). MS (ES) [m+H] calc'd for C6H7N2OCl, 159, 161; found 159, 161.

出典と根拠

ORDレコード
ord-2fa0d23379444feeb525cb1742f255cc
出典データセット
uspto-grants-2009_08
特許番号
US07579357B2

反応ノート

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