Triethylamine → HCID 57447109、化合物

HRID 2105462ノート

反応式

HRID 2105462 の反応式
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].C(N(CC)CC)C.[NH2:14][C:15]1[CH:16]=[N:17][C:18]2[C:23]([C:24]=1[Cl:25])=[CH:22][CH:21]=[CH:20][CH:19]=2>ClCCl>[Cl:25][C:24]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=[CH:16][C:15]=1[NH:14][C:1](=[O:5])[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 8855Butyryl chlorideHCID 8173324-chloroquinolin-3-amine

生成物 1

HCID 57447109HCID 57447109、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Butyryl chloride (3.77 mL, 1.3 eq) and triethylamine (5.85 mL, 1.3 eq) were added sequentially to a chilled (0° C.) solution of 3-amino-4-chloroquinoline (5.0 g, 1.0 eq) in dichloromethane (100 mL). The reaction mixture was warmed to ambient temperature and then allowed to stir overnight. The reaction mixture was quenched with aqueous saturated sodium bicarbonate. The organic layer was separated and concentrated under reduced pressure to provide 6.5 g of N-(4-chloroquinolin-3-yl)butyramide.

後処理

  1. customThe reaction mixture was quenched with aqueous saturated sodium bicarbonate
  2. customThe organic layer was separated
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-6e9f40f6bb0c408e8d1e99dead1287cb
出典データセット
uspto-grants-2009_08
特許番号
US07579359B2

反応ノート

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