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1-[2-(2-Hydroxyethoxy)ethyl]piperazine → 4-Chloro-7-{1-(tert-butoxycarbonyl)-5-[4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-ylmethyl]indol-2-yl}isoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-[2-(2-Hydroxyethoxy)ethyl]piperazine | HCID 139436 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 4-Chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone | HCID 86628227 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Chloro-7-{1-(tert-butoxycarbonyl)-5-[4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-ylmethyl]indol-2-yl}isoindolinone | HCID 68492503 | — |
反応手順
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 1-[2-(2-hydroxyethoxy)ethyl]piperazine (35 mg, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-{1-(tert-butoxycarbonyl)-5-[4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-ylmethyl]indol-2-yl}isoindolinone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-a10796da6bff45cfa8a6359052c5bf45 |
| 出典メモ | uspto-grants-2010_06 |