HCID 669172、化合物 → 4-amino-N-(2-phenylethyl)benzenesulfonamide
反応式
[C:1]1([CH2:7][CH2:8][NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([NH:19]C(=O)C)=[CH:15][CH:14]=2)(=[O:12])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O1CCOCC1>[C:1]1([CH2:7][CH2:8][NH:9][S:10]([C:13]2[CH:14]=[CH:15][C:16]([NH2:19])=[CH:17][CH:18]=2)(=[O:12])=[O:11])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
3
実験手順
To a solution of 23 (0.6 g, 1.7 mmol) in dioxane (8 ml) 20% NaOH is added (13 ml) and the mixture is refluxed for 1.5 hours. The solvent is concentrated under reduced pressure and the aqueous phase is added with 20% NaOH to pH=7. The resulting solid is filtered under reduced pressure, washed with water and dried to give compound 24 as white solid (0.43 g, 83% yield).
後処理
- temperaturethe mixture is refluxed for 1.5 hours
- concentrationThe solvent is concentrated under reduced pressure
- additionthe aqueous phase is added with 20% NaOH to pH=7
- filtrationThe resulting solid is filtered under reduced pressure
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-6be5395a1bea4a3b9bc378ec832df66b
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07579378B2
反応ノート
読み込み中…