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Methyl acetoacetate → Cyclohexylmethyl-5-(2,5-difluoro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | trans-2-Aminomethyl-1-cyclohexanol | HCID 2724658 | — |
| 反応物 | 2-Bromo-1-(2,5-difluorophenyl)ethanone | HCID 2778264 | — |
| 生成物 | Cyclohexylmethyl-5-(2,5-difluoro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ((1RS,2RS)-2-hydroxy-cyclohexylmethyl)-amide | HCID 72485423 | — |
反応手順
The title compound was synthesized in analogy to Example 68, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-(2,5-difluorophenyl)-ethanone as compound of formula S, c-cyclohexyl-methylamine as R3—(CH2)m—NH2 and trans-2-aminomethyl-1-cyclohexanol as R1R2NH, MS (ISP) 445.5 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07579369B2 |
| 出典データセット | uspto-grants-2009_08 |
| ORD ID | ord-0febccc59e2040a58c152fcb8a3b1f45 |
| 出典メモ | uspto-grants-2009_08 |