Dimethyl Sulfoxide → 2-[2-(5-Bromo-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane

HRID 2106014ノート

反応式

HRID 2106014 の反応式
[F:1][C:2]([F:19])([F:18])[C:3](=[O:17])[CH2:4][C:5]([C:8]1[CH:13]=[C:12]([Br:14])[CH:11]=[CH:10][C:9]=1[O:15][CH3:16])([CH3:7])[CH3:6].[CH3:20]S(C)=O>>[Br:14][C:12]1[CH:11]=[CH:10][C:9]([O:15][CH3:16])=[C:8]([C:5]([CH3:7])([CH3:6])[CH2:4][C:3]2([C:2]([F:1])([F:18])[F:19])[CH2:20][O:17]2)[CH:13]=1

参加物

3

反応物 2

HCID 679Dimethyl SulfoxideHCID 46938920HCID 46938920、化合物

生成物 1

HCID 578097532-[2-(5-Bromo-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane

実験手順

To a solution of 1,1,1-trifluoro-4-(5-bromo-2-methoxyphenyl)-4-methylpentan-2-one (5 g, 14.7 mmol) in 5 mL of anhydrous DMSO at room temperature was added 14.6 mL of the ylide stock solution (17.3 mmol) over 5 minutes. The reaction was quenched after 2 hours with water and diethyl ether. The aqueous layer was extracted with diethyl ether. The combined organic layers were washed with water and brine, dried over magnesium sulfate, filtered, and concentrated in vacuo to afford 2-[2-(5-bromo-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane as a dark yellow oil.

後処理

  1. customThe reaction was quenched after 2 hours with water and diethyl ether
  2. extractionThe aqueous layer was extracted with diethyl ether
  3. washThe combined organic layers were washed with water and brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5f94526d6f414b84b75d2f16ab78fcb4
出典データセット
uspto-grants-2009_08
特許番号
US07579469B2

反応ノート

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