Sodium Chloride → HCID 57809879、化合物
反応式
COC(=O)[CH:4]([C:17]#[N:18])[C:5]1([CH3:16])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([F:15])[CH:13]=2)[O:8][CH2:7][CH2:6]1.[Cl-].[Na+]>CS(C)=O.O>[F:15][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[O:8][CH2:7][CH2:6][C:5]2([CH2:4][C:17]#[N:18])[CH3:16]参加物
5
実験手順
A mixture of 3.1 g (11.8 mmol) of cyano-(6-fluoro-4-methylchroman4-yl)acetic acid methyl ester and 2.47 g (42.4 mmol) of sodium chloride in 30 mL of wet DMSO was warmed to reflux. The reaction was monitored by TLC. After 4 hours, the reaction was cooled and diluted with water and extracted with diethyl ether. The combined organic layers were washed with four portions of water, brine, dried over magnesium sulfate, and concentrated in vacuo to afford 2.1 g (87%) of (6-fluoro-4-methylchroman-4-yl)acetonitrile as an oil.
後処理
- temperaturewas warmed to reflux
- temperaturethe reaction was cooled
- extractionextracted with diethyl ether
- washThe combined organic layers were washed with four portions of water, brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-8aaea83030f3457b9223d9a1d5274e9d
- 出典データセット
- uspto-grants-2009_08
- 特許番号
- US07579469B2
反応ノート
読み込み中…