Hydrochloric Acid → 2,3,4,5-Tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazinehydrochloride

反応式

[O:1]=[C:2]1[N:7]([N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:16])=[N:4][NH:3]1.[ClH:17]>>[ClH:17].[O:1]=[C:2]1[N:7]([N:8]=[CH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH2:6][C:5]([CH3:16])=[N:4][NH:3]1

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 863704,5-Dihydro-6-methyl-4-((3-pyridinylmethylene)amino)-1,2,4-triazin-3(2H)-one

生成物 1

HCID 679245022,3,4,5-Tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazinehydrochloride

実験手順

21.7 g of 2,3,4,5-tetrahydro-3-oxo-4-[(pyridin-3-yl)-methyleneamino]-6-methyl-1,2,4-triazine are dissolved, with heating, in 60 ml of 2N hydrochloric acid. The hot solution is filtered and cooled. The precipitate which crystallises out is isolated by filtration, washed with alcohol and ether and dried in vacuo to give the title compound of formula ##STR32## in the form of a colourless crystal powder; m.p. 240-241° C. with decomposition; yield: 19 g (75%).

後処理

filtrationThe hot solution is filtered
temperaturecooled
customThe precipitate which crystallises out
customis isolated by filtration
washwashed with alcohol and ether
customdried in vacuo

出典と根拠

ORDレコード: ord-10518bb3c4774c4e8e131818f65ec661
出典データセット: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04931439

反応ノート

読み込み中…

参加物