Methane → (Piperidin-4-yl)methanol--hydrogen chloride (1/1)
反応式
[ClH:1].C([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[CH2:11][CH2:10]1)C1C=CC=CC=1.C>C(O)C>[ClH:1].[NH:9]1[CH2:14][CH2:13][CH:12]([CH2:15][OH:16])[CH2:11][CH2:10]1参加物
4
実験手順
105 g of 1-benzyl-4-piperidinemethanol hydrochloride, 2 l of ethanol and 12.5 g of palladinized charcoal are introduced into a Parr bottle, and a hydrogenolysis is performed at 50° C. under a pressure of 0.4 MPa. The mixture is filtered and the filtrate evaporated off under reduced pressure. 58.7 g of solid are obtained. Melting point: 128°-130° C.
後処理
- customis performed at 50° C. under a pressure of 0.4 MPa
- filtrationThe mixture is filtered
- customthe filtrate evaporated off under reduced pressure
出典と根拠
- ORDレコード
- ord-79cc2909bb1e424c8c898567924181d3
- 出典データセット
- uspto-grants-1990_06
- 特許番号
- US04931449
反応ノート
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