(Triphenylphosphoranylidene)acetaldehyde → HCID 15596448、化合物

HRID 2106861ノート

反応式

HRID 2106861 の反応式
[C:1]1([C:7]#[C:8][CH2:9][CH2:10][CH:11]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:13]([CH:15]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:14]>C(Cl)Cl>[C:1]1([C:7]#[C:8][CH2:9][CH2:10]/[CH:11]=[CH:15]/[CH:13]=[O:14])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 75051(Triphenylphosphoranylidene)acetaldehydeHCID 112406334-Pentynal, 5-phenyl-

生成物 1

HCID 15596448HCID 15596448、化合物収率 42.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

5-Phenylpent-4-ynal (0.5 g) in CH2Cl2 (5 ml) was added to a solution of formylmethylenetriphenyl phosphorane (1.8 g) in CH2Cl2 (10 ml) and the mixture was stirred at room temperature under a dry nitrogen atmosphere for 24 hours. The solvent was removed under reduced pressure and the residue was slurried with ether (50 ml), filtered, and the residue washed with ether. The ethereal solutions were combined and the product was purified by chromatography on silica eluting with ether:hexane (1:9) to yield 7-phenylhept-2E-en-6-ynal (0.25 g) as a yellow oil.

後処理

  1. customThe solvent was removed under reduced pressure
  2. filtrationfiltered
  3. washthe residue washed with ether
  4. customthe product was purified by chromatography on silica eluting with ether:hexane (1:9)

出典と根拠

ORDレコード
ord-705997d5e42841a5b2fa7ec5efb10efc
出典データセット
uspto-grants-1990_06
特許番号
US04931469

反応ノート

読み込み中…