Triphenylphosphine → (tert-Butoxycarbonylmethyl)triphenylphosphonium Bromide

HRID 2106870ノート

反応式

HRID 2106870 の反応式
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][CH2:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]>C1C=CC=CC=1>[Br-:20].[C:22]([CH2:21][P+:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23]

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 79177tert-Butyl bromoacetate

生成物 1

HCID 2733853(tert-Butoxycarbonylmethyl)triphenylphosphonium Bromide収率 96%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A solution of triphenylphosphine (33.8 g, 129 mmol) and t-butyl bromoacetate (25 g, 128.2 mmol) in dry benzene (150 ml) was stirred for 16 hours at room temperature. The precipitated product was collected by filtration, washed with dry ether and dried in vacuo to give 56 g (96% of theory) of carbo-t-butoxymethyl triphenylphosphonium bromide.

後処理

  1. filtrationThe precipitated product was collected by filtration
  2. washwashed with dry ether
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-f6b3f10780de4177b168c8ba64a75c9b
出典データセット
uspto-grants-1990_06
特許番号
US04931469

反応ノート

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