Triethylamine → 3-fluoro-N-(1-methyl-1-phenylethyl)benzamide

HRID 21070

反応式

HRID 21070 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[C:11]([NH2:20])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([CH3:13])[CH3:12].C(N(CC)CC)C>ClCCl.CN(C1C=CN=CC=1)C>[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:20][C:11]([CH3:13])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:12])=[O:6]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 68509CumylamineHCID 743763-Fluorobenzoyl chloride

生成物 1

HCID 474447463-fluoro-N-(1-methyl-1-phenylethyl)benzamide収率 95.3%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

In a similar manner to Step 1 of Example 16, 3-fluorobenzoyl chloride (2.00 g, 12.6 mmol) was dissolved in dichloromethane (40 mL), and the solution was treated with cumylamine (1.99 mL, 13.9 mmol), triethylamine (2.63 mL, 18.9 mmol) and DMAP (154 mg, 1.26 mmol). The mixture was purified by slurry using diisopropylether to obtain 3-fluoro-N-(1-methyl-1-phenylethyl)benzamide (3.09 g, yield 95%).

後処理

  1. customThe mixture was purified by slurry

出典と根拠

ORDレコード
ord-604da105a25148b5894cebf65055674a
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

関連ノート

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