Benzaldehyde → Ethyl 2-hydroxy-5-benzylideneaminobenzoate

反応式

[OH:1][C:2]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH:14](=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[OH:1][C:2]1[CH:12]=[CH:11][C:10]([N:13]=[CH:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]

参加物

反応物 2

HCID 240Benzaldehyde

HCID 13445456Ethyl 5-amino-2-hydroxybenzoate

生成物 1

HCID 23047228Ethyl 2-hydroxy-5-benzylideneaminobenzoate収率 67%

反応条件

温度: 100 °C

実験手順

Ethyl 2-hydroxy-5-aminobenzoate (31.8 g, 0.176 mole) was mixed with benzaldehyde (17.8 ml, 0.176 mole), and the mixture was heated to 100° C. for 10 minutes and subsequently cooled with ice-water. The resulting oil was recrystallized from 96% ethanol, with activated carbon, to give the title compound (31.6 g, 67%), m.p. 63°-65° C. Found (Calc. for C16H15NO3) C 71.18 (71.38), H 5.63 (5.58), N 5.22 (5.20).

後処理

customThe resulting oil was recrystallized from 96% ethanol, with activated carbon

出典と根拠

ORDレコード: ord-a9ae4075f2c84f2a906151a1c67138b7
出典データセット: uspto-grants-1990_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04933330

反応ノート

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