Ammonia → HCID 23047741、化合物
反応式
[NH3:1].Cl[C:3]([CH:5]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[O:4]>C(Cl)Cl>[NH2:1][C:3]([CH:5]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[O:4]参加物
4
実験手順
A saturated solution of gaseous ammonia in 25 ml of methylene chloride is added drop by drop at -10° C. to a solution of 5.6 (17 mmol) of ethyl 2-(chlorocarbonyl)-7-(4-chlorophenyl)heptanoate in 50 ml of methylene chloride. The mixture is stirred for 30 minutes at room temperature, suction filtered from the ammonium chloride, the filtrate is washed with water, and dried and concentrated. The concentrate is chromatographed on silica gel with a mixture of toluene and dioxane (5:1). 3.6 g (68% of theory) is obtained of ethyl 2-(aminocarbonyl)-7-(4-chlorophenyl)heptanoate, M.P. 110°-111° C.