Triethylamine → 2-(p-Fluoroanilino)thiazole-4-carbaldehyde

HRID 2107275ノート

反応式

HRID 2107275 の反応式
[F:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6][C:7]2[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=2)=[CH:4][CH:3]=1.C(N(CC)CC)C>CS(C)=O>[F:1][C:2]1[CH:15]=[CH:14][C:5]([NH:6][C:7]2[S:8][CH:9]=[C:10]([CH:12]=[O:13])[N:11]=2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 8471TriethylamineHCID 150535552-p-Fluoroanilinothiazol-4-ylmethanol

生成物 1

HCID 150535722-(p-Fluoroanilino)thiazole-4-carbaldehyde

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

The reaction described in Preparation 44 was repeated, but using 3.03 g of 2-p-fluoroanilinothiazol-4-ylmethanol, 8.5 g of pyridine sulfur trioxide complex, 7.5 ml of triethylamine and 140 ml of dimethyl sulfoxide. giving the title compound as pale brown prisms.

後処理

  1. customThe reaction described in Preparation 44

出典と根拠

ORDレコード
ord-866a9f38546e4b30bba6e3e0351639df
出典データセット
uspto-grants-1990_06
特許番号
US04933355

反応ノート

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