Triethylamine → 3-methoxy-N-(1-methyl-1-phenylethyl)benzamide

HRID 21074

反応式

HRID 21074 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].[C:12]([NH2:21])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([CH3:14])[CH3:13].C(N(CC)CC)C>ClCCl.CN(C1C=CN=CC=1)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([NH:21][C:12]([CH3:14])([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH3:13])=[O:7]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 68509CumylamineHCID 74374m-Anisoyl chloride

生成物 1

HCID 474447523-methoxy-N-(1-methyl-1-phenylethyl)benzamide収率 98.2%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒

実験手順

In a similar manner to Step 1 of Example 16, 3-methoxybenzoylchloride (8.00 g, 46.9 mmol) was dissolved in dichloromethane (160 mL), and the solution was treated with cumylamine (7.40 mL, 51.6 mmol), triethylamine (9.80 mL, 70.4 mmol) and DMAP (573 mg, 4.69 mmol), followed by purification by slurry using diisopropylether to obtain 3-methoxy-N-(1-methyl-1-phenylethyl)benzamide (12.4 g, yield 98%).

後処理

  1. customfollowed by purification by slurry

出典と根拠

ORDレコード
ord-3ae2376e5a64468fa46f09c86691de66
出典データセット
uspto-grants-2010_06
特許番号
US07745641B2

関連ノート

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