Urea → N-(2-Amino-2-methylpropyl)urea

HRID 2107566ノート

反応式

HRID 2107566 の反応式
[NH2:1][CH2:2][C:3]([NH2:6])([CH3:5])[CH3:4].[NH2:7][C:8](N)=[O:9]>O>[CH3:4][C:3]([NH2:6])([CH3:5])[CH2:2][NH:1][C:8]([NH2:7])=[O:9]

参加物

4

反応物 2

HCID 1176UreaHCID 131282-Methylpropylenediamine

生成物 1

HCID 13603863N-(2-Amino-2-methylpropyl)urea

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Alternatively, the urea of this example was prepared as follows: A mixture of 26.5 g (0.3 mol) of 1,2-diamino-2-methylpropane, and 18 g (0.3 mol) of urea in 150 ml of water was refluxed for 4 hours. The mixture was evaporated in vacuo. The residue was dissolved in chloroform, filtered and evaporated to form a solid which was recrystallized in ethyl acetate to give 15 g of product (38%), m.p. 87°-90° C. The NMR and IR spectra were consistent with the assigned structre.

後処理

  1. temperaturewas refluxed for 4 hours
  2. customThe mixture was evaporated in vacuo
  3. dissolutionThe residue was dissolved in chloroform
  4. filtrationfiltered
  5. customevaporated
  6. customto form a solid which
  7. customwas recrystallized in ethyl acetate

出典と根拠

ORDレコード
ord-6d997594f23249eb873f083e343f9c0d
出典データセット
uspto-grants-1990_06
特許番号
US04935421

反応ノート

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