Sodium Cyanide → 2,3,6-Trifluorophenylacetonitrile
反応式
[C-:1]#[N:2].[Na+].[F:4][C:5]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([F:14])[C:6]=1[CH2:7]Cl>O.[Cl-].C1([N+](CC)(CC)CC)C=CC=CC=1>[F:4][C:5]1[C:12]([F:13])=[CH:11][CH:10]=[C:9]([F:14])[C:6]=1[CH2:7][C:1]#[N:2]参加物
5
実験手順
To a solution of sodium cyanide (1.94 g) in water (4 ml) is added phenyltriethylammonium chloride (0.09 g), and thereto is added with stirring 2,3,6-trifluorobenzyl chloride (5.0 g), and the mixture is stirred at 90° to 100° C. for 40 minutes. The reaction mixture is poured into water (20 ml) and is extracted with diethyl ether. The extract is dried over potassium carbonate and the solvent is distilled off to give 2-(2,3,6-trifluorophenyl)acetonitrile (3.1 g), b.p. 80°-85° C. (5 mmHg).
後処理
- extractionis extracted with diethyl ether
- dry with materialThe extract is dried over potassium carbonate
- distillationthe solvent is distilled off
出典と根拠
- ORDレコード
- ord-06fc2dde16c241dbb20200937d01fed6
- 出典データセット
- uspto-grants-1990_06
- 特許番号
- US04935420
反応ノート
読み込み中…