Water → Ethyl 2-(2,3,6-trifluorophenyl)acetate
反応式
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][C:11]#N.S(=O)(=O)(O)O.[CH2:18]([O:20]CC)[CH3:19].[OH2:23]>C(O)C>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][C:11]([O:20][CH2:18][CH3:19])=[O:23]参加物
6
反応条件
- 温度
- 125 °C
実験手順
2-(2,3,6-Trifluorophenyl)acetonitrile (13.3 g) is dissolved in ethanol (20 ml), and thereto is carefully added conc. sulfuric acid (8.5 ml), and the mixture is refluxed at 125° C. for 7 hours. After cooling, the reaction mixture is fractionated with diethyl ether and water. The ether layer is washed with aqueous saturated sodium chloride and dried over magnesium sulfate and then concentrated under reduced pressure to give ethyl 2-(2,3,6-trifluorophenyl)acetate (16.3 g), as colorless oil.
後処理
- temperatureAfter cooling
- washThe ether layer is washed with aqueous saturated sodium chloride
- dry with materialdried over magnesium sulfate
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-44db64504766465cbe5cd0376a49cc38
- 出典データセット
- uspto-grants-1990_06
- 特許番号
- US04935420
反応ノート
読み込み中…