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Hydrochloric Acid → Boc-Pro-Thr(OBzl)-OH

HRID 2107784
ノート
印刷プレビュー

反応式

HRID 2107784 の反応式
[N:1]1([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:15][CH2:14][CH2:13][C@H:2]1[C:3]([O:5]N1C(=O)CCC1=O)=O.N1(C(OC(C)(C)C)=O)[CH2:30][CH2:29][CH2:28][C@H:24]1[C:25](O)=O.[NH2:38][C@H:39]([C:43]([OH:45])=[O:44])[C@@H](C)O.C([O-])(O)=O.[Na+].Cl.O1[CH2:57][CH2:56][O:55][CH2:54][CH2:53]1>O>[N:1]1([C:16]([O:18][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:17])[CH2:15][CH2:14][CH2:13][C@H:2]1[C:3]([NH:38][C@H:39]([C:43]([OH:45])=[O:44])[C@@H:54]([CH3:53])[O:55][CH2:56][C:57]1[CH:25]=[CH:24][CH:28]=[CH:29][CH:30]=1)=[O:5]
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 6

HCID 313Hydrochloric AcidHCID 6288L-ThreonineHCID 312751,4-DioxaneHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 516892Sodium BicarbonateHCID 8538831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-(2,5-dioxo-1-pyrrolidinyl) ester, (2S)-2 回

生成物 1

HCID 14836683Boc-Pro-Thr(OBzl)-OH

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Boc-Pro-Thr(OBzl)-OH was prepared by coupling Boc-Pro-OSu (the N-hydroxysuccinamide ester of Boc-Pro-OH) to H-Thr (OBzl) - OH. H-Thr (OBzl)-OH.HCL was dissolved in 25 ml of water, NaHCO3 (6.21 g, 73.9 mmoles) and a solution of Boc-Pro-Osu (5.07 g, 16.25 mmoles) in 25 ml of dioxane were added. After stirring 3 hours, the reaction mixture was acidified with hydrochloric acid and the product extracted into ethyl acetate. It was washed with 0.2N HCl prepared in saturated aqueous NaCl, saturated NaCl and dried over anhydrous Na2SO4. Solvent was evaporated to yield 6.24 g (mp 120°-12.5°).

後処理

  1. extractionthe product extracted into ethyl acetate
  2. washIt was washed with 0.2N HCl
  3. customprepared in saturated aqueous NaCl
  4. dry with materialsaturated NaCl and dried over anhydrous Na2SO4
  5. customSolvent was evaporated
  6. customto yield 6.24 g (mp 120°-12.5°)

出典と根拠

ORDレコード
ord-a140bd7236e34961af77af8874e44fb7
出典データセット
uspto-grants-1990_06
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04935493

反応ノート

読み込み中…

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