Hydrochloric Acid → Methyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride

反応式

[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].Cl.[CH3:15]O>>[ClH:13].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([NH2:12])[C:9]([Cl:13])=[CH:8][C:4]=1[C:5]([O:7][CH3:15])=[O:6]

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 816264-Amino-5-chloro-2-methoxybenzoic acid

生成物 1

HCID 23046717Methyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride

実験手順

A suspension of 30 g (0.15 mol) of 2-methoxy-4-amino-5-chlorobenzoic acid in 500 ml methanol is cooled to 0° and the mixture treated with gaseous HCl for 30 minutes. After all the acid dissolves the solution is evaporated to dryness to obtain methyl 2-methoxy-4-amino-5-chlorobenzoate hydrochloride which is used directly in the next step.