Diphenyl carbonate → 3-(4-Methoxybenzyl)thiazolidin-2-one
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][NH:10][CH2:11][CH2:12][SH:13])=[CH:5][CH:4]=1.[C:14](=O)(OC1C=CC=CC=1)[O:15]C1C=CC=CC=1>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]2[CH2:11][CH2:12][S:13][C:14]2=[O:15])=[CH:5][CH:4]=1参加物
4
実験手順
A solution containing 4.53 g (0.025 mol) of N-(4-methoxyphenylmethyl)-cysteamine and 5.35 g (0.025 mol) of diphenyl carbonate in 25 ml of ethanol is refluxed under nitrogen for 24 hours, then evaporated. The residue is taken up in ethyl acetate, washed with 2N sodium hydroxide solution until it becomes free from phenol, then washed with water, dried and evaporated. The residue becomes solid under ether. Thus, 1.82 g (32.6%) of the title compound are obtained, m.p.: 84°-86° C.
後処理
- temperatureis refluxed under nitrogen for 24 hours
- customevaporated
- washwashed with 2N sodium hydroxide solution until it
- washwashed with water
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-9ef934f1ce8042f59c3b127ca83ef784
- 出典データセット
- uspto-grants-1990_06
- 特許番号
- US04937252
反応ノート
読み込み中…