Potassium Iodide → HCID 23045048、化合物

HRID 2108037ノート

反応式

HRID 2108037 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.CC(=O)[CH2:17][C:18](=[O:20])[CH3:19].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(O)C.CCOCC>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[CH2:8][CH2:7][O:6][CH2:5][CH2:4][CH2:3][CH2:2][CH2:17][C:18](=[O:20])[CH3:19]

参加物

7

反応物 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 31261AcetylacetoneHCID 230450722-[2-(4-Bromobutoxy)ethyl]pyridine

生成物 1

HCID 23045048HCID 23045048、化合物収率 83.3%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 2-[2-[(4-bromobutyl)oxy]ethyl]pyridine (6.2 g), 2,4-pentanedione (3.61 g), potassium carbonate (4.75 g) and potassium iodide (3.95 g) in ethanol (125 ml) was stirred and heated overnight under reflux. The solids were removed by filtration and the filtrate evaporated to leave a dark brown semi-solid. Addition of ether (200 ml) and filtration of the solid produced a brown solution which was evaporated to give a brown oil (4.71 g). Purification by FCC eluting with ether-hexane (1:1→3:1) gave the title compound as a pale yellow oil (1.93 g).

後処理

  1. temperatureheated overnight
  2. temperatureunder reflux
  3. customThe solids were removed by filtration
  4. customthe filtrate evaporated
  5. customto leave a dark brown semi-solid
  6. customproduced a brown solution which
  7. customwas evaporated

出典と根拠

ORDレコード
ord-db34ccea9f4b4518acbcdfeabed8f586
出典データセット
uspto-grants-1990_06
特許番号
US04937251

反応ノート

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