Benzoyl chloride, 3,4-dichloro- → 3,4-Dichloro-N-[2-(6,7-dimethoxyquinazolin-4-ylamino)benzo-thiazol-6-yl]benzamide
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5](Cl)=[O:6].[CH3:12][O:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][C:23]=1[O:24][CH3:25])[N:20]=[CH:19][N:18]=[C:17]2[NH:26][C:27]1[S:28][C:29]2[CH:35]=[C:34]([NH2:36])[CH:33]=[CH:32][C:30]=2[N:31]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5]([NH:36][C:34]1[CH:33]=[CH:32][C:30]2[N:31]=[C:27]([NH:26][C:17]3[C:16]4[C:21](=[CH:22][C:23]([O:24][CH3:25])=[C:14]([O:13][CH3:12])[CH:15]=4)[N:20]=[CH:19][N:18]=3)[S:28][C:29]=2[CH:35]=1)=[O:6]参加物
3
実験手順
3,4-Dichloro-N-[2-(6,7-dimethoxyquinazolin-4-ylamino)benzo-thiazol-6-yl]benzamide was prepared from 3,4-dichlorobenzoyl chloride (24 mg, 0.113 mmol) and N2-(6,7-dimethoxyquinazolin-4-yl)benzothiazole-2,6-diamine (40 mg, 0.113 mmol) according to GP 2 (yellowish solid, 49 mg, 92 μmol, 82%). LC/ESI-MS: m/z=526 [M(35Cl2)+H]+; m/z=524 [M(35Cl2)−H]−; Rt=3.82 min.
出典と根拠
- ORDレコード
- ord-f9360148873549798081596f13f1fd8a
- 出典データセット
- uspto-grants-2009_04
- DOI