4-Chloro-2-(trifluoromethyl)phenyl isocyanate → 1-(4-Chloro-2-trifluoromethylphenyl)-3-[2-(6,7-dimethoxyquinazolin-4-ylamino)benzothiazol-6-yl]urea

HRID 2108919

反応式

HRID 2108919 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[C:4]([C:11]([F:14])([F:13])[F:12])[CH:3]=1.[CH3:15][O:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][C:26]=1[O:27][CH3:28])[N:23]=[CH:22][N:21]=[C:20]2[NH:29][C:30]1[S:31][C:32]2[CH:38]=[C:37]([NH2:39])[CH:36]=[CH:35][C:33]=2[N:34]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:39][C:37]2[CH:36]=[CH:35][C:33]3[N:34]=[C:30]([NH:29][C:20]4[C:19]5[C:24](=[CH:25][C:26]([O:27][CH3:28])=[C:17]([O:16][CH3:15])[CH:18]=5)[N:23]=[CH:22][N:21]=4)[S:31][C:32]=3[CH:38]=2)=[O:10])=[C:4]([C:11]([F:12])([F:13])[F:14])[CH:3]=1

参加物

3

反応物 2

HCID 27332644-Chloro-2-(trifluoromethyl)phenyl isocyanateHCID 86248039N2-(6,7-dimethoxyquinazolin-4-yl)benzothiazole-2,6-diamine

生成物 1

HCID 231325011-(4-Chloro-2-trifluoromethylphenyl)-3-[2-(6,7-dimethoxyquinazolin-4-ylamino)benzothiazol-6-yl]urea

実験手順

1-(4-Chloro-2-trifluoromethylphenyl)-3-[2-(6,7-dimethoxyquinazolin-4-ylamino)benzothiazol-6-yl]urea was prepared from 4-chloro-2-(trifluoromethyl)phenyl isocyanate (17 μL, 0.113 mmol) and N2-(6,7-dimethoxyquinazolin-4-yl)benzothiazole-2,6-diamine (40 mg, 0.113 mmol) according to GP 3. The solid was filtered off and washed thoroughly with dichloromethane to obtain a yellow solid (27 mg, 48 μmol, 42%). LC/ESI-MS: m/z=575 [M(35Cl)+H]+; m/z=573 [M(35Cl)−H]−; Rt=3.79 min.

後処理

  1. filtrationThe solid was filtered off
  2. washwashed thoroughly with dichloromethane

出典と根拠

ORDレコード
ord-8f9189dced77400b9340f2039c60b129
出典データセット
uspto-grants-2009_04
特許番号
US07514460B2

関連ノート

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