2-Butyne-1,4-diol → 4-(Tetrahydro-pyran-2-yloxy)-but-2-yn-1-ol
反応式
[CH2:1]([OH:6])[C:2]#[C:3][CH2:4][OH:5].[O:7]1[CH:12]=[CH:11][CH2:10][CH2:9][CH2:8]1>CCOCC>[O:7]1[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]1[O:5][CH2:4][C:3]#[C:2][CH2:1][OH:6]参加物
4
実験手順
To a mixture of 5.0 g of 2-butyne-1,4-diol and 10 milligrams of p-toluenesulfonic add and 150 ml of dry ether there was added dropwise with stirring at room temperature 4.9 g of 3,4-dihydro-2H-pyran. After stirring overnight at ambient temperature the ether was evaporated and the residue was poured into 200 ml of water. The aqueous solution was extracted with hexane (2×100 ml) and then re-extracted with ether (3×100 ml). The combined ether extracts were washed with 100 ml of brine, dried over magnesium sulfate and evaporated to yield 6.8 g of 4-tetrahydropyranoxy-2-butyn-1-ol.
後処理
- additionof p-toluenesulfonic add
- customwas evaporated
- additionthe residue was poured into 200 ml of water
- extractionThe aqueous solution was extracted with hexane (2×100 ml)
- extractionre-extracted with ether (3×100 ml)
- washThe combined ether extracts were washed with 100 ml of brine
- dry with materialdried over magnesium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-5e3cc0d24c92424b96fce5ec22cba17e
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05728698
反応ノート
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