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(2-Methoxyethyl)(methyl)amine → n2-(5-Chloropyridin-2-yl)-n5-(methoxyethyl)-n5-methyl-3-{[5-(3-oxomorpholin-4-yl)pentanoyl]amino}furo[3,2-b]pyridine-2,5-dicarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Methoxyethyl)(methyl)amine | HCID 300977 | — |
| 反応物 | 2-{[(5-Chloropyridin-2-yl)amino]carbonyl}-3-{[5-(3-oxomorpholin-4-yl)pentanoyl]amino}furo[3,2-b]pyridine-5-carboxylic acid | HCID 57633400 | — |
| 生成物 | n2-(5-Chloropyridin-2-yl)-n5-(methoxyethyl)-n5-methyl-3-{[5-(3-oxomorpholin-4-yl)pentanoyl]amino}furo[3,2-b]pyridine-2,5-dicarboxamide | HCID 57633276 | 75% |
反応手順
2-{[(5-Chloropyridin-2-yl)amino]carbonyl}-3-{[5-(3-oxomorpholin-4-yl)pentanoyl]amino}furo[3,2-b]pyridine-5-carboxylic acid (82 mg) obtained in Example 139 and N-(2-methoxyethyl)methylamine (28 mg) are treated in a similar manner to Example 85 to give the title compound (70 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07514449B2 |
| 出典データセット | uspto-grants-2009_04 |
| ORD ID | ord-2165f6df56cc4e908eff36551565e510 |
| 出典メモ | uspto-grants-2009_04 |