3-[4-(5-Methoxy-pyridin-3-yl)-[1,2,3]triazol-1-yl]-4-methyl-benzoic acid → N-[3-Methanesulfonylamino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-3-[4-(5-methoxy-pyridin-3-yl)-[1,2,3]triazol-1-yl]-4-methyl-benzamide
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[N:11][N:12]([C:14]3[CH:15]=[C:16]([CH:20]=[CH:21][C:22]=3[CH3:23])[C:17](O)=[O:18])[CH:13]=2)[CH:6]=[N:7][CH:8]=1.[NH2:24][C:25]1[C:26]([O:40][CH3:41])=[C:27]([NH:35][S:36]([CH3:39])(=[O:38])=[O:37])[CH:28]=[C:29]([C:31]2([CH3:34])[CH2:33][CH2:32]2)[CH:30]=1>>[CH3:39][S:36]([NH:35][C:27]1[C:26]([O:40][CH3:41])=[C:25]([NH:24][C:17](=[O:18])[C:16]2[CH:20]=[CH:21][C:22]([CH3:23])=[C:14]([N:12]3[CH:13]=[C:9]([C:5]4[CH:6]=[N:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=4)[N:10]=[N:11]3)[CH:15]=2)[CH:30]=[C:29]([C:31]2([CH3:34])[CH2:32][CH2:33]2)[CH:28]=1)(=[O:38])=[O:37]参加物
3
反応物 2
生成物 1
実験手順
Example 12 was prepared by coupling 3-[4-(5-methoxy-pyridin-3-yl)-[1,2,3]triazol-1-yl]-4-methyl-benzoic acid with N-[3-amino-2-methoxy-5-(1-methyl-cyclopropyl)-phenyl]-methanesulfonamide (U.S. Ser. No. 04/102,492) in the same manner as Example 1. LST MS m/z 563 [C28H30N6O5S+H]+.