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4-Bromophenol → 4-(2,3,5,6-Tetramethylbenzyloxy)bromobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromophenol | HCID 7808 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-(Chloromethyl)-1,2,4,5-tetramethylbenzene | HCID 81939 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 4-(2,3,5,6-Tetramethylbenzyloxy)bromobenzene | HCID 23062453 | 79% |
反応手順
In acetone (50 ml), a mixture of 4-bromophenol (7.8 g), 2,3,5,6-tetramethylbenzyl chloride (6.3 g) and potassium carbonate (6.5 g) was heated at reflux for 16 hours. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, and successively washed with 3% aqueous sodium hydroxide solution, water and saturated brine. The solvent was evaporated under reduced pressure, thereby giving 8.7 g of the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07514452B2 |
| 出典データセット | uspto-grants-2009_04 |
| ORD ID | ord-52c09326b92d4d6db679987c70e3e86c |
| 出典メモ | uspto-grants-2009_04 |