Furan, 2-bromo- → (R)-3'-(Furan-2-yl)spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one

反応式

[O:1]1[C@@:5]2([CH:10]3[CH2:11][CH2:12][N:7]([CH2:8][CH2:9]3)[CH2:6]2)[CH2:4][NH:3][C:2]1=[O:13].Br[C:15]1[O:16][CH:17]=[CH:18][CH:19]=1>>[O:16]1[CH:17]=[CH:18][CH:19]=[C:15]1[N:3]1[CH2:4][C@:5]2([CH:10]3[CH2:11][CH2:12][N:7]([CH2:8][CH2:9]3)[CH2:6]2)[O:1][C:2]1=[O:13]

参加物

反応物 2

HCID 2776190Furan, 2-bromo-

HCID 5310971AR-R-17779

生成物 1

HCID 57634249(R)-3'-(Furan-2-yl)spiro[1-azabicyclo[2.2.2]octan-3,5'-oxazolidin]-2'-one

実験手順

The title compound was prepared by a method analogous to that described in Preparation 3 from (S)-spiro[1-azabicyclo[2.2.2]octan-3,5′-oxazolidin]-2′-one and 2-bromofuran. The title compound (1.49 g) was obtained as a pale-yellow solid, m/z 249 (MH+).

後処理

customThe title compound was prepared by a method analogous to

出典と根拠

ORDレコード: ord-7f11c7d4e41148e68e19f49c7ad9f87f
出典データセット: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07514567B2

反応ノート

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