4-Methylphenyl isocyanate → HCID 23023097、化合物

HRID 2110082ノート

反応式

HRID 2110082 の反応式
[C:1]1([CH3:10])[CH:6]=[CH:5][C:4]([N:7]=[C:8]=[O:9])=[CH:3][CH:2]=1.[CH3:11][O:12][C:13]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([C:22]([F:25])([F:24])[F:23])=[CH:16][C:14]=1[NH2:15]>CCOC(C)=O>[CH3:11][O:12][C:13]1[CH:19]=[C:18]([O:20][CH3:21])[C:17]([C:22]([F:24])([F:23])[F:25])=[CH:16][C:14]=1[NH:15][C:8]([NH:7][C:4]1[CH:5]=[CH:6][C:1]([CH3:10])=[CH:2][CH:3]=1)=[O:9]

参加物

4

反応物 2

HCID 693254-Methylphenyl isocyanateHCID 27800032,4-dimethoxy-5-(trifluoromethyl)aniline

生成物 1

HCID 23023097HCID 23023097、化合物収率 89.9%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

p-Tolyl isocyanate (0.16 mL, 1.24 mmol) was added to a solution of 2,4-dimethoxy-5-(trifluoromethyl)aniline (0.25 g, 1.13 mmol) in EtOAc (3 mL) and the resulting mixture was stirred at room temp. for 18 h. The resulting precipitate was washed with Et2O to give the title compound as a white solid (0.36 g): 1H-NMR (CDCl3) δ 2.21 (s, 3H), 3.97 (s, 3H), 3.86 (s, 3H), 6.88 (s, 1H), 7.05 (d, J=8.5 Hz, 2H), 7.29 (d, J=8.5 Hz, 2H), 8.13 (s, 1H), 8.33 (s, 1H), 9.09 (s, 1H); FAB-MS m/z 355 ((M+1)+). B1e. General Method for the Reaction of an Aryl Amine with an Aryl Isocyanate

後処理

  1. washThe resulting precipitate was washed with Et2O

出典と根拠

ORDレコード
ord-5db46d012927401393f118a0eb664905
出典データセット
uspto-grants-2009_04
特許番号
US07517880B2

反応ノート

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