6-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol → 7-Methoxy-1,2-dihydronaphthalene

HRID 2110979

反応式

HRID 2110979 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9](O)[CH2:8][CH2:7][CH2:6]2>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10]([CH:9]=[CH:8][CH2:7][CH2:6]2)=[CH:11][CH:12]=1

参加物

3

反応物 1

HCID 110522116-Methoxy-1,2,3,4-tetrahydronaphthalen-1-ol

生成物 1

HCID 5947787-Methoxy-1,2-dihydronaphthalene収率 96%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
115 °C

実験手順

Crude 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol (10.3 g, 0.058 mol) was dissolved in 100 ml of toluene and heated in an oil bath (115° C.). P-tolylsulphonic acid (20 mg) was added to the reaction mixture and it was refluxed for about 1 h. The reaction was monitored by GC. The reaction mixture was then cooled and washed with sat. NaHCO3 solution, water and brine and organic layer was dried over Na2SO4. Concentration gave 8.87 g of light brown oil. Yield 96%.

後処理

  1. temperaturewas refluxed for about 1 h
  2. temperatureThe reaction mixture was then cooled
  3. washwashed with sat. NaHCO3 solution, water and brine and organic layer
  4. dry with materialwas dried over Na2SO4
  5. concentrationConcentration

出典と根拠

ORDレコード
ord-7c095eeee5fd44d19f6edf1be616582b
出典データセット
uspto-grants-2009_04
特許番号
US07517992B2

関連ノート

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