Ethanone, 1-(2-chlorophenyl)- → (1R)-1-(2-chlorophenyl)ethan-1-ol

HRID 2111007ノート

反応式

HRID 2111007 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:10])[CH3:9].B(Cl)([C@@H]1[C@@H](C)[C@H]2C(C)(C)[C@@H](C2)C1)[C@@H]1[C@@H](C)[C@@H]2C(C)(C)[C@@H](C2)C1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C@H:8]([OH:10])[CH3:9]

参加物

3

反応物 2

HCID 72864Ethanone, 1-(2-chlorophenyl)-HCID 91873398(+)-b-Chlorodiisopinocamphenylborane

生成物 1

HCID 6999092(1R)-1-(2-chlorophenyl)ethan-1-ol収率 73.3%

実験手順

Reaction was carried out using 2′-chloroacetophenone (11.90 g, 76.77 mmol) and (+)-B-chlorodiisopinocamphenylborane ((+)-DIP-C1) (25.00 g, 77.88 mmol) and according to J. Org. Chem., 1985, vol. 50, p. 5446; and 1988, vol. 53, p. 2916, to give the title compound (8.81 g, 72%). The optical purity was determined by HPLC analysis using an optically active column after conversion to the acetate (using acetic anhydride and triethylamine in dichloromethane).

後処理

  1. customReaction

出典と根拠

ORDレコード
ord-759029748a754e1a80c65d045cb79a19
出典データセット
uspto-grants-2009_04
特許番号
US07517996B2

反応ノート

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