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4-Vinylbenzaldehyde → 4-Vinylbenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Vinylbenzaldehyde | HCID 39389 | — |
| 反応物 | HCID 178418634 | HCID 178418634 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Vinylbenzaldehyde | HCID 39389 | — |
| 生成物 | Benzaldehyde, 2-ethenyl- | HCID 39391 | — |
反応手順
Aldehyde 11 was synthesized by radical addition (Lub et al. (1997) Liebigs Ann. Recueil, 2281-2288) of thioacetic acid to 4-vinylbenzaldehyde. Vinyl benzaldehyde was synthesized by the procedure of Ren et al. (1993) Bull. Chem. Soc. Jpn. 66: 1897-1902 with the following changes: The addition of DMF was performed at a 38 mmol scale at 0° C. Purification by column chromatography (silica, Et2O/hexanes, 1:3) afforded 4-vinylbenzaldehyde in 60% yield (FIG. 37)/
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07518905B2 |
| 出典データセット | uspto-grants-2009_04 |
| ORD ID | ord-bf61f8e028394939abd8e955c70d1b94 |
| 出典メモ | uspto-grants-2009_04 |