Methyl 4-(bromomethyl)benzoate → HCID 57637614、化合物

HRID 2111480ノート

反応式

HRID 2111480 の反応式
[C:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:20]=[CH:19][C:17]([O-:18])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[Na+].Br[CH2:23][C:24]1[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=1>CC(C)=O>[C:1]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[CH:16][C:17]([O:18][CH2:23][C:24]3[CH:33]=[CH:32][C:27]([C:28]([O:30][CH3:31])=[O:29])=[CH:26][CH:25]=3)=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

参加物

4

反応物 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 57637585Sodium 4-(1-BOC-piperazin-4-yl)phenoxide

生成物 1

HCID 57637614HCID 57637614、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
60 °C

実験手順

Sodium 4-(1-BOC-piperazin-4-yl)phenoxide (1 equivalent) and methyl 4-bromomethylbenzoate (1 equivalent) were combined in dry acetone and heated to reflux at 60° C. for 18 hours. The slurry was filtered and the filtrate was then concentrated to provide the crude methyl 4-[4-(1-BOC-piperazin-4-yl)phenoxymethyl]benzoate, which was used without purification.

後処理

  1. temperatureheated
  2. filtrationThe slurry was filtered
  3. concentrationthe filtrate was then concentrated

出典と根拠

ORDレコード
ord-5a253b5ce8144f62bbfdf3348beb500e
出典データセット
uspto-grants-2009_04
特許番号
US07521062B2

反応ノート

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