4,5-Dimethoxyphthalic acid → 5,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dione

HRID 2111616

反応式

HRID 2111616 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:14]([OH:16])=[O:15])[C:6](=[CH:10][C:11]=1[O:12][CH3:13])[C:7]([OH:9])=O>C(OC(=O)C)(=O)C>[CH3:13][O:12][C:11]1[CH:10]=[C:6]2[C:7](=[O:9])[O:16][C:14](=[O:15])[C:5]2=[CH:4][C:3]=1[O:2][CH3:1]

参加物

3

反応物 1

HCID 2909884,5-Dimethoxyphthalic acid

生成物 1

HCID 6103565,6-Dimethoxy-1,3-dihydro-2-benzofuran-1,3-dione収率 48%

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

The product of above-mentioned (b) (4.1 g, 18 mmol) was heated under reflux in acetic anhydride (14 ml) for 10 minutes. The reaction solution was poured into ice-cold water, and extracted with chloroform. The organic layer was washed with an aqueous saturated sodium bicarbonate solution and then water, dried and concentrated under reduced pressure to give 1.8 g of the title compound.

後処理

  1. additionThe reaction solution was poured into ice-cold water
  2. extractionextracted with chloroform
  3. washThe organic layer was washed with an aqueous saturated sodium bicarbonate solution
  4. dry with materialwater, dried
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d9ad4222b2b14916aec932ed1497abd8
出典データセット
uspto-grants-2009_04
特許番号
US07521451B2

関連ノート

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