4-Aminophenol → 2-ethyl-3-(4-hydroxyphenyl)quinazolin-4(3H)-one

HRID 2111815ノート

反応式

HRID 2111815 の反応式
[CH2:1]([C:3]1O[C:7](=[O:9])[C:6]2[CH:10]=[CH:11][CH:12]=[CH:13][C:5]=2[N:4]=1)[CH3:2].[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1>CN(C)C=O>[CH2:1]([C:3]1[N:14]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)[C:7](=[O:9])[C:6]2[C:5](=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=1)[CH3:2]

参加物

4

反応物 2

HCID 4034-AminophenolHCID 9285262-Ethyl-benzo[d][1,3]oxazin-4-one

生成物 1

HCID 7113732-ethyl-3-(4-hydroxyphenyl)quinazolin-4(3H)-one収率 66%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
140 °C

実験手順

2-ethyl-4H-3,1-benzoxazin-4-one (6.5 g, 37.1 mmol) and 4-aminophenol (4.05 g, 37.1 mmol) were dissolved in dimethylformamide (18 mL) and stirred at 140° C. for 10 hours. After leaving to cool to room temperature, distilled water (94 mL) was added, and the solid precipitate was filtered off. The product was recrystallized (ethanol) and the target compound (6.52 g, 66%) was obtained as light brown crystals.

後処理

  1. customAfter leaving
  2. temperatureto cool to room temperature
  3. distillationdistilled water (94 mL)
  4. additionwas added
  5. filtrationthe solid precipitate was filtered off
  6. customThe product was recrystallized (ethanol)

出典と根拠

ORDレコード
ord-93b3e362c05a4cf5aeb85de1366b427a
出典データセット
uspto-grants-2009_04
特許番号
US07521455B2

反応ノート

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