Hydrochloric Acid → 5-[4-(4-(2-(2-Aminopropanamido)-2-methoxycarbonylethyl)phenoxy)benzyl]thiazolidin-2,4-dione Hydrochloride

HRID 2111879ノート

反応式

HRID 2111879 の反応式
C(OC([NH:8][CH:9]([CH3:40])[C:10]([NH:12][CH:13]([C:36]([O:38][CH3:39])=[O:37])[CH2:14][C:15]1[CH:35]=[CH:34][C:18]([O:19][C:20]2[CH:33]=[CH:32][C:23]([CH2:24][CH:25]3[S:29][C:28](=[O:30])[NH:27][C:26]3=[O:31])=[CH:22][CH:21]=2)=[CH:17][CH:16]=1)=[O:11])=O)(C)(C)C.[ClH:41]>ClCCl>[ClH:41].[NH2:8][CH:9]([CH3:40])[C:10]([NH:12][CH:13]([C:36]([O:38][CH3:39])=[O:37])[CH2:14][C:15]1[CH:35]=[CH:34][C:18]([O:19][C:20]2[CH:33]=[CH:32][C:23]([CH2:24][CH:25]3[S:29][C:28](=[O:30])[NH:27][C:26]3=[O:31])=[CH:22][CH:21]=2)=[CH:17][CH:16]=1)=[O:11]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 219896705-[4-(4-(2-(2-t-Butoxycarbonylaminopropanamido}2-methoxycarbonylethyl)phenoxy)benzyl]thiazolidin-2,4-dione

生成物 1

HCID 219896635-[4-(4-(2-(2-Aminopropanamido)-2-methoxycarbonylethyl)phenoxy)benzyl]thiazolidin-2,4-dione Hydrochloride収率 66.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 5-[4-(4-(2-(2-t-butoxycarbonylaminopropanamido)-2-methoxycarbonyl ethyl)phenoxy)benzyl]thiazolidin-2,4-dione (1 g, 1.75 mmol) in dichloromethane (10 ml) was bubbled with HCl gas at −10° C. for 50 minutes. The excess HCl gas was removed by N2 bubbling and concentrated to dryness to afford the title compound (0.59 g, yield 66.3%).

後処理

  1. customThe excess HCl gas was removed by N2 bubbling
  2. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-fbaedaea79a54c4a87738fb3ed4e6d12
出典データセット
uspto-grants-2009_04
特許番号
US07521466B2

反応ノート

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